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To confirm GF status, microbiological assays were performed on a monthly basis by culturing feces, bedding, and drinking water in thioglycollate medium (DIFCO, Camarillo, CA)

Pathological crosstalk between IL-17A and NR1D1 enables interventions in the circadian rhythm network through NR1D1 activation or inhibition of the upstream polarizing signal RORt ( 2.4.2 Direct neutralization strategies: clinical setbacks and the necessity for stratified therapy Anti-IL-17A monoclonal antibodies are effective in diseases such as psoriasis, but their clinical translation in COPD faces bottlenecks