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Amgen started Phase III trials of MariTide, a once-monthly dual GLP-1 receptor agonist and GIP receptor antagonist, in March
Mechanistically, it acts systemically: it sequesters G-actin, promotes endothelial cell migration in scratch-wound assays, and has shown progenitor-cell mobilization signals in preclinical cardiac models
Proton donation by GSH to form a free radical is also described though it differs in that the free radical formed can pair with another GSH radical to produce GSSG or extract a hydrogen radical to form new radicals and reform GSH
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