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The fold change in expression of each gene was calculated using the comparative DDCt method, with GAPDH as housekeeping reference endogenous control

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GHK-Cu is the rational primary choice for users with sensitive or reactive skin, those with a history of retinoid intolerance, individuals managing rosacea or compromised barrier function, and anyone specifically targeting skin density, firmness, and hydration rather than primarily pigmentation and surface texture

Chen X, Huang Q, Feng J, Xiao Z, Zhang X, Zhao L