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GLP-1 is one of the key hormonal components of the intestinal traffic control mechanism known as the ileal brake, which regulates the rate of nutrient transit and absorption

19 Substitution with Aib 8 hardly influences the cAMP activity and substitution with D-Ala 8 induces little or no change in the affinity or cAMP activity

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[sources 15] [204] Beyond its G s - and G 13 -coupled receptor-mediated effects on monoamine transporter function, TAAR1 also opens G protein-coupled inwardly rectifying potassium channels through a separate pathway, an action that reduces neuronal firing