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They may present as macular, plaque like, or as a mass, wellcircumscribed or irregular, and may exhibit focal or diffuse areas of brown, blue, or black pigmentation (Figure 512)

Some research protocols have explored doses up to 4.5 mg weekly, which showed slightly greater efficacy in the phase 2 dose-finding trial but also increased side effect burden

It stimulates the pigment cells in your skin to produce more melanin, and this makes the skin look darker