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It also has a boxed warning and is labeled by the FDA as a most serious medication warning because it causes risk of thyroid C-cell tumors
MDSCs suppress effector T cells through mechanisms such as arginase production and induction of Treg cell differentiation, thus fostering immunosuppression [180, 181]
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In the CIBERSORT dataset, memory activated CD4+ T cells decreased in GLP-1R-high primary and metastatic tissue when compared to both GLP-1R-low groups, while resting CD4+ T cells increased in the GLP-1R-high groups ( Figure 4b )
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