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Participants were assigned to receive weekly doses of retatrutide at 1 mg, 4 mg, 8 mg, or 12 mg for 48 weeks, or placebo

In Lau et al., gastrointestinal disorders occurred in 4163% of cagrilintide participants (0.34.5 mg) versus 32% of placebo, primarily nausea at 2047% versus 18% [5]

Pairing with SPF 30+ sunscreen amplifies the effect significantly glutathione reduces melanin synthesis from within, sunscreen blocks the UV trigger from outside