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Among all actively pursued DUB targets, USP7/HAUSP is the most studied due to its critical role in regulating p53 function

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Key finding: NNMT overexpression drives satellite cell senescence pharmacological inhibition with 5-Amino-1MQ restored stem cell activation to levels comparable to young animals

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doi: 10.4269/ajtmh.13-0467 18 PearceEJMacDonaldAS

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