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On top of that, the injectable form carries the same practical drawbacks as other injectable peptides: needles, sterile reconstitution, refrigeration, degradation after mixing, and the ongoing friction of maintaining a regular injection routine for benefits that build gradually over months

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This shortening is a well-known biomarker of aging and is associated with increased risks of cancer, cardiovascular disease, neurodegeneration, and metabolic disorders Blackburn et al., Nature , 2006