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This is due to an enzyme called dipeptidyl peptidase-4, or the DPP-4 enzyme, which rapidly degrades natural GLP-1, making it too fleeting to provide a lasting therapeutic benefit for blood sugar control or weight management
Patients with cardiovascular risk factors may therefore find a GLP-1RA more appropriate owing to the improvements in cardiometabolic parameters that have been observed with this drug class [10, 37, 46, 47]
Phase II study of personalized peptide vaccination for castration-resistant prostate cancer patients who failed in docetaxel-based chemotherapy
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