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seen in ~20% of RF+ patients Pulmonary involvement : interstitial lung disease (ILD), pleural effusion, pulmonary nodules, bronchiolitis obliterans Cardiac involvement : pericarditis, myocarditis, accelerated atherosclerosis, conduction abnormalities Ocular involvement : scleritis, episcleritis, keratoconjunctivitis sicca (secondary Sjgrens), uveitis (H20.x code separately) Vasculitis : digital infarcts, skin ulceration, mononeuritis multiplex, mesenteric ischemia (severe/rare) Feltys syndrome triad : RA + splenomegaly + neutropenia associated with M05.0x codes Anemia of chronic disease

But a comprehensive investigation of the physiological basis underlying cucumber plant responses to the HT stress is still lacking

& Nemcovsky, C

The Philippine FDAs 2025 advisory specifically warns about toxic effects on the nervous system