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In normoxia, hydroxylation of HIF- by PHDs enables its interaction with pVHL (von Hippel-Lindau protein) and targets subunits for ubiquitination and proteasomal degradation [140]
Physicians should direct the treatment at the underlying mechanisms outlined above.
L-carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans
63 They secrete proinflammatory chemokines and cytokines such as monocyte chemotactic protein 1 (MCP-1), 64 prostaglandin E2 (PGE2), 65 interleukin 1 (IL-1), 66 IL-6, 67 IL-10, 67 tumor necrosis factor (TNF) and regulated on activation normal T cell expressed and secreted (RANTES)
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