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Phosphorylated STAT1 enters the nucleus and directly inhibits the cystine/glutamate antiporter system Xc= (composed of SLC7A11 and SLC3A2), resulting in a 60%-80% reduction in GSH synthesis and a 3-5-fold increase in lipid peroxidation levels due to impaired GPX4 activity (219, 221)
In simple language, GLP-1 receptor agonists are medicines that copy the action of a natural gut hormone released after eating
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