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Consequently, a significant proportion of administered nanocarriers is prematurely sequestered and cleared by the reticuloendothelial system (RES)particularly the liver and spleensubstantially limiting the effective dose that reaches the osteosarcoma TME (69, 70)
doi: 10.1016/j.ejphar.2009.12.023 134 McCleanP
women planning pregnancy should stop treatment before conceiving
As IGF-1R mAbs are readily available for human use, these observations warrant further study into potentially harnessing these drugs to target at least some manifestations of aging
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