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As body weight decreases, total daily energy expenditure decreases, and the deficit that produced rapid early weight loss narrows
Direct answer: semaglutide is injected once a week into the fat layer just under the skin the abdomen (at least two inches from the navel), the front of the thigh, or the back of the upper arm
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It also acts on the hypothalamusthe part of the brain responsible for homeostatic hunger, or the physical need for fuel
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