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20 In relation to bone, GLP-2 receptors have been detected in osteoblast-like cell lines such as MG-63 and TE-85, 59 but presence in mature osteoblasts and other bone-related cells is yet to be confirmed
That level of response suggests the dose escalation was too aggressive, and stepping back to the previous dose for an additional four weeks is the standard intervention
Microdosing semaglutide simply reduces GLP-1 activation proportionally, while microdosing tirzepatide disproportionately reduces the GLP-1 component while relatively preserving the GIP component
Endocrinology (2003) 144:144455
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