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The dual nature of type I and type II interferons
As a subtype of glial cells vital for retina structural support, cellular homeostasis maintenance, and blood-retina barrier preservation, its reactivation would decrease lglutamic acid uptake, which results in excitotoxicity, as well as sabotage the integrity of the blood-retina barrier, leading to ultimate retinal ganglia cell death and vision damage (Ren et al., 2020)
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