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Individuals who suffer from pernicious anemia do not produce the necessary intrinsic factor for B12 absorption
When any component fails, oral supplementation becomes far less effective, potentially requiring massive doses to achieve therapeutic blood levels
Efficacy of supplementation with methylcobalamin and cyancobalamin in maintaining the level of serum holotranscobalamin in a group of plantbased diet (vegan) adults. Experimental and Therapeutic Medicine 22(3) (2021): 17
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