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The G subunit is believed to play a modulatory role, with a stimulating effect for AC2, AC4, and AC7, and an inhibiting effect for AC1 and AC8 (Jiang et al., 2006)
The titration schedule typically looks like this: Weeks 1-4: 0.25 mg weekly Weeks 5-8: 0.5 mg weekly Weeks 9-12: 1.0 mg weekly Weeks 13-16: 1.7 mg weekly Week 17 onward: 2.4 mg weekly (maintenance) This gradual approach helps minimize gastrointestinal side effects, which are the most common complaint during the first few weeks
Psychopharmacology (Berl) 112 : 398402 Di Chiara G, Loddo P, Tanda G
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