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The peptide agonist retains an -helical conformation as it sits deep within the receptor-binding pocket
Slower digestion means more time for gut bacteria to ferment food, which can produce gas, and more time for the colon to reabsorb water, which can make stool harder to pass
However, patients with type 2 diabetes were included in these trials [52, 53], which could have contributed to the observed differences
Diet-related deficiency is more rare than mal-absorption
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