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5-Amino-1MQ is a substrate-mimetic inhibitor that occupies the nicotinamide binding site, with a reported IC of 1.2 0.1 M (Neelakantan et al., J Med Chem, 2017)

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Yilmaz M, MD, Kantarjian H, MD, Short NJ, MD, Konopleva M, MD, PhD, Kadia TM, MD, DiNardo CD, MD, MSCE, Borthakur G, MD, Pemmaraju N, MD, Maiti A, MBBS, Jabbour EJ, MD, Issa GC, MD, Jain N, MD, Takahashi K, MD, PhD, Sasaki K, MD, PhD, Ohanian M, DO, Tang G, MD, PhD, Loghavi S, MD, Patel K, MD, PhD, Garcia-Manero G, MD, Andreeff M , MD, PhD, Ravandi F, MBBS, Daver N, MD

Animal and cell studies show promise in areas like fertility and ovarian support, yet human trials remain sparse