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The injection is given intramuscularly, usually into the upper arm (deltoid) or buttock (gluteal muscle)

Several studies have demonstrated that the GLP-1 receptor agonists such as extendin-4 and liraglutide can activate AMPK signalling in multiple tissues and cell types, including cardiomyocyte hyperglycaemic [20] or cardiac hypertrophy models [21], in rat INS-1 pancreatic beta cells [22], and in L6 myotubes, resulting in the sensitisation of insulin-stimulated glucose uptake [23]

SGLT-2 inhibitors and GLP-1RA should, therefore, be considered evidence-based treatments for patients with type 2 diabetes after metformin

In decreasing order of abundance, seven phenolic acids and one phenolic aldehyde were found in oats, including cinnamic, ferulic, p-coumaric, vanillic, syringic, 2,4-dihydroxybenzoic, syringaldehyde, and o-coumaric acids