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How Weight Loss Affects Nerves: Peripheral nerves are surrounded by fat Rapid fat loss changes nerve microenvironment Mechanical stress as tissues shrink around nerves Altered blood flow to nerves as vascular beds change Supporting Evidence: Higher doses (more weight loss) = more dysesthesia Doesn't occur early (takes time for substantial weight loss) Not seen with slower weight loss medications Theory 3: Metabolic Changes Retatrutide produces dramatic metabolic shifts: improved insulin sensitivity, altered lipid metabolism, changed glucose homeostasis

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