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This neurochemical adjustment typically improves as your body acclimates to the medication over 48 weeks
Participants also recorded reductions in waist circumference (average 7.1cm loss on 6mg, 8.2cm on 12mg, 10cm on 36mg, compared with 3.1cm loss on placebo), blood pressure (estimated -4.2 and -1mm HG difference between placebo and orforglipron in systolic and diatolic blood pressure, respectively) and cholesterol (-2.1% difference between placebo and orforglipron)
Neurosteroids play a role in anxiety and in the learning and memory deficits associated with certain anxiety disorders
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