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This reduced variability may provide benefits beyond what average glucose levels indicate, since glucose fluctuations themselves appear to contribute to metabolic dysfunction and vascular damage
In clinical studies, 400mg taken daily with diet and exercise supported meaningful reductions in BMI, waist, and hip measurements after just four weeks
Moreover, studies have shown that the inflammatory response of RIRI can increase vascular leakage and participate in the death of retinal ganglion cells
Diabetes Care 44 (6), 13851392
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