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With a molecular weight of approximately 4731 g/mol and a molecular formula of C221H342N46O68 (though some sources note C223H343F3N46O70 due to trifluoroacetate salt variations), Retatrutides structure supports its role as a triple agonist targeting glucagon (GCGR), glucose-dependent insulinotropic polypeptide (GIPR), and glucagon-like peptide-1 (GLP-1R) receptors

The pain can range from tingling and numbness to sharp, stabbing sensations and may exhibit temperature variations such as burning or cold

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Starting low minimizes GI distress and allows gradual adaptation