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An examination using murine models of coronary artery tying appeared to exhibit results which implied that TB-500 might elevate integrin-associated kinase (ILK) and protein kinase B operations in the heart, possibly boosting early cardiomyocyte endurance and seemingly enhancing heart performance

On the human side, the record is sparse

For 10mg vials referenced in longer protocols or higher-dose escalation 2mL is also commonly cited and yields a higher concentration that keeps injection volumes manageable at 8-12mg doses