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In the case of these mutual interactions, a major factor that should be noticed is the accessibility of vitamin A, which is dependent on the equilibrium between the enzymes which are responsible for the production or inactivation of the RA RAR or could be limiting in rigorous nutritional deficiencies (180)
This information is essential to encourage payers to expand access to these medications earlier in the course of diabetes and irrespective of HbA 1c levels
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