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5.3 GLP-1s anti-inflammatory effects GLP-1 receptor agonists significantly reduce inflammation by modulating immune cell activity and suppressing the release of pro-inflammatory cytokines, such as TNF- , IL-6, and IL-1 (99101)

However, the lack of standardized formulations means that researchers must often develop their own administration protocols

These reactions were observed in clinical trials: Abdominal distension Abdominal pain Acute gallbladder disease Acute kidney injury Acute pancreatitis Allergic reactions Constipation Diarrhea Dizziness Dyspepsia (indigestion) Eructation (burping) Fatigue Flatulence Gastroenteritis Gastroesophageal reflux disease Headache Hypoglycemia (in diabetic patients) Nasopharyngitis (cold) Nausea Thyroid C-cell tumors Vomiting Studies, consumer reports and lawsuits have highlighted other side effects of semaglutide medications

There are no formal human clinical trials supporting the safety or efficacy of this specific combination