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It is not surprising, therefore, that erythromycin is associated with marked acceleration or dumping of food from the stomach since, as a motilin receptor agonist and stimulant of cholinergic mechanisms, it enhances both fundic contraction as well as antral motor function, thereby having a dual effect on mechanisms associated with increased longitudinal axial forces in the antrum in healthy participants and patients with dysmotilities and acceleration of gastric emptying (Surrenti et al., 1996
These findings have expanded the scope of BPC-157 research beyond its originally studied pathways
BPC-157 is a linear chain of fifteen residues: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Val Four structural features explain much of its experimental behaviour: near the N-terminus impose conformational rigidity and resist enzymatic cleavage, which accounts for its unusual stability relative to most short peptides
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