In the STEP 1 semaglutide trial (Wilding et al., NEJM , 2021) and the SURMOUNT-1 tirzepatide trial (Jastreboff et al., NEJM , 2022), nausea affected roughly 44% of semaglutide patients and about 24% of tirzepatide patients at the maximum dose
Specifically, ROS can oxidize and inactivate MAPK phosphatases (MKPs), which normally dephosphorylate and deactivate MAPKs
At your appointment, a medical professional will evaluate your health, discuss your weight loss goals, and determine if weight loss injections like Semaglutide or Tirzepatide are suitable for you
The study's authors noted this kind of database research can't confirm a direct causal link between the medication and these events, so it's best read as a signal for further investigation rather than proof of cause and effect