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This high cost, along with limited manufacturing supply, means usage has remained mostly concentrated in wealthier countries (notably the US and parts of Europe) and among patients who can afford to pay

Americas Health Insurance Plans (AHIP), the health insurance industrys largest trade group, submitted comments to CMS in February saying the costs of covering the drugs could place upward pressure on premiums and government costs. The Congressional Budget Office estimated in October 2024 that requiring Medicare to cover GLP-1s for obesity would add nearly $35 billion to federal spending by 2034

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muciniphila also raised the release of ECs