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Specifically, Phase 3 trials are also exploring its efficacy in treating osteoarthritis and metabolic dysfunction-associated steatohepatitis (MASH), formerly known as fatty liver disease

The 2.0mL option at 10mg/mL still works for the 4-8mg range but becomes impractical for 12mg doses since you would need to draw 120 units, which exceeds the capacity of a standard 100-unit insulin syringe

When treatment is titrated toward weight loss rather than glycemic control, average reductions can be much larger, with a trial-level result of 14.9% body weight loss over 68 weeks under a weight-focused escalation protocol

Common side effects reported in clinical trials include nausea, diarrhea, vomiting, constipation, stomach pain, and injection site reactions