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Description

Presented for research literature review only

Antibodies directed against the mid portion of glucagon (cross-reacting antisera) not only react with glucagon but also with other proglucagon by-products, glicentin, glucagon 1-61 and oxyntomodulin, and thus are of limited use

Symptoms are typically dose-related and occur early in treatment, with many patients seeing improvement within a few weeks as the body adapts to slower gastric emptying and central effects