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PYY 136 is a gut hormone that binds to the Y1-R in pancreatic islets and central nervous system (CNS) nuclei that control appetite regulation in the brain including the brainstem area postrema (AP) and nucleus tractus solitarius (NTS), where it has an orexigenic effect 18

Sugary foods can cause stomach aches, Levy says

It helps in weight loss through several mechanisms such as appetite regulation, insulin sensitivity improvement, blood sugar level regulation, slowed gastric emptying, increased fat oxidation, energy expenditure enhancement, and hormonal balance modulation

This is why both medications are generally considered long-term therapies rather than short-term interventions