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Resistance arises through multiple mechanisms, including mutations and duplications in Ace1 and the overexpression of detoxifying enzymes 8,12,13,14,15,16,17,18,19,20,21,22
Symptoms to Watch For New or changing skin lesion Non-healing sore Bleeding or crusting mole Itching, tenderness, or pain Risk Factors Excessive UV exposure (sunlight or tanning) History of sunburns, especially intermittent intense exposure Fair skin, freckles, light hair/eyes Family or personal history of skin cancer Immunosuppression Diagnosis & Advances - Clinical examination and dermoscopy - Excisional biopsy (preferred for suspicious lesions) - Treatment advances include: Surgical excision (early-stage disease) Immunotherapy (checkpoint inhibitors) Targeted therapy (BRAF/MEK inhibitors) The Take-Home Message Melanoma is highly treatable when detected early, but delays can lead to spread and poorer outcomes
Its important to explore your options and choose the medication that feels like the perfect fit for your goals and long-term success
A Canadian Public Health Association article published by McMaster University Master of Public Health candidate Sadiqa Sheikh states that an estimated 3 million Canadian adults are taking GLP-1 receptor agonists as of early 2026, making Canada the second-largest user of GLP-1s in the world
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