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The administration of this drug in mice and rats with induced intestinal inflammation resulted in a reduction in intestinal motility, weight gain, shortening of the colon, macroscopic damage, diarrhea, MPO activity, inflammatory infiltrate, bodyweight loss, and nitrite levels, leading to an improvement in the inflammatory condition of the animals [52,85,102,106,127]

The nausea usually gets better after a few weeks, but those first few weeks can be rough

Research has also explored niacinamide's anti-inflammatory mechanisms at the molecular level