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Presented for research literature review only Liu X et al
Freie Radikale greifen Zellmembranen, Kollagenstrukturen und die zellulre DNA an
One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)
(PubMed) Violi F, Pignatelli P
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