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Finally, it is crucial to explore the key enzymes involved in CAT production by gut microbiota metabolism and their regulatory factors, evaluate the therapeutic potential of engineered probiotics (e.g., CAT-synthesizing strains) or exogenous CAT delivery systems (e.g., cartilage-targeted nanocarriers) for OA, and provide multi-level evidence for CAT-targeted OA therapy based on the gut-joint axis
Patients often report a shift in how their body responds to food and exercise
Of the 23 patients included, initial mean body weight, BMI and waist circumference were 102.9 Kg, 35.6 and 119.5 cm respectively
Avoid using strong oxidants at the same time 2.To avoid the simultaneous use of components that can be complexed with copper ions, such as carnosine, EDTA, etc
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