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d , Uptake of indicated concentrations of [ 13 C 2 , 15 N]-GSH into mitochondria isolated from parental HEK-293T mitotag cells for 10 min
The potential molecular mechanisms underlying these effects included disturbances in redox homeostasis (as evidence by the enhanced production of ROS and reactive nitrogen species), failure of enzymatic and nonenzymatic cytoprotective mechanisms involving the glutathione system as well as nuclear factor kappa B (NF-B) and fibroblast growth factor 2-mediated pathways, and impaired mitochondrial function
Stalmans S, et al
Research investigations may include peptide signaling interactions, cellular communication studies, and experimental mechanism analysis
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