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(ii) comprehensive pharmacokinetic, biodistribution, and long-term toxicology profiles validated in large-animal models (e.g., canine osteosarcoma, which closely mimics human disease)

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Ethyl Ascorbic Acid, a highly stable vitamin C derivative, works to reduce melanin production which is the main cause of hyperpigmentation, while Tranexamic Acid and pearl extract restore the skin's natural equilibrium and promote skin cell regeneration, resulting in a naturally smooth, radiant complexion

The latter is subdivided into apoptotic and non-apoptotic cell death