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Like the rest of this blend, the fat-loss evidence is preclinical, and human outcome data does not yet exist
POPs are mainly excreted through conjugation with GSH and this mechanism is extremely important for the health status, since exposure to POPs has been associated to diabetes, cardiovascular diseases and many other chronic diseases ( ROS production can occur at several intracellular sites but, for most cells, takes place in the mitochondria and the mitochondrial electron transport chain is the main cellular process of ROS generation in physiological circumstances ( 2 O 2 )
However, at 37C, high DAB staining is found in the meristem, while NBT is lower, suggesting that high temperatures lead to a change in O 2 .- /H 2 O 2 balance (Supplemental Figure 2 E-H)
However, these effects have not been firmly established in large human clinical trials
