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The Final Word The good news for federal employees and annuitants is that all FEHB plans currently cover at least one weight-loss medication

Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

These receptors are found in the hypothalamus, hippocampus, amygdala, and in areas associated with the mesolimbic reward pathway

Since muscle is a major energy utilizer 17,41 , minimizing muscle mass during caloric restriction can substantially reduce energy expenditure, thus sparing energy for the maintenance of other more critical organ systems 42,43,44