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282,283 These cells accumulate in the synovial membrane and subchondral bone, releasing pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which promote the degradation of joint cartilage and the inflammatory response
PMID: 32398685 Biomater Res Albumin Nanocages with Methotrexate and Chondroitin Sulfate as a Dual pH/GSH-Responsive Tumor Targeting Nanomedicine for Synergistic Cancer Therapy
More serious digestive complications, including pancreatitis, are considered possible but appear to be uncommon based on current research
Key publications: 'Stimulation of collagen synthesis in fibroblast cultures by GHK-Cu' (1988, FEBS Letters), 'In vivo stimulation of connective tissue accumulation by GHK-Cu' (1993), 'GHK-Cu stimulates matrix metalloproteinase-2 expression' (2000)
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