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Some of the discrepancies with earlier mouse studies can be accounted for by different adaptations made by T cells based on their surrounding environment, which differs enormously based on whether the T cells are activated in vitro versus in vivo ( Interestingly, the cellular energy sensor AMP-activated protein kinase (AMPK), a known driver of oxidative metabolism and mediator of FAO, has also been implicated in promoting Th1 versus Th2 differentiation
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The results are inconsistent, the side effects are unpredictable, and the conclusions are unreliable
Kuo B, Scimia C, Dukes G et al (2021) Randomised clinical trial: safety, pharmacokinetics and pharmacodynamics of trazpiroben (TAK-906), a dopamine D2 /D3 receptor antagonist, in patients with gastroparesis
