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Simultaneously, it suppresses the hepatic synthesis of sex hormone-binding globulin (SHBG), further elevating free testosterone levels (8, 13, 20)

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These changes were paralleled by elevated antioxidant capacity, as shown by increases in several antioxidant enzymes including SOD, catalase and glutathione peroxidase

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It acts by binding to nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction, causing prolonged depolarization of skeletal muscle cells

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doi: 10.2337/dc21-S009 7 ZinmanBWannerCLachinJMFitchettDBluhmkiEHantelSet al

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