CSF sub-study A CSF sub-study is being conducted in 15 countries as part of evoke and evoke+ to explore the effect of semaglutide on CSF biomarkers, including markers of AD, neuroinflammation, neurodegeneration, BBB integrity, oxidative stress, synaptic integrity, and vascular integrity (Table 3)
The Innovation of Sublingual Administration The introduction of sublingual administration represents a groundbreaking shift in the way Semaglutide is delivered
Kaplan-Meier analysis was used to estimate the probability of the primary outcome over time, with censoring applied for patients exiting the cohort
GLP-1R agonists Several GLP-1R agonists, which mainly delay protease DPP-4 metabolism to overcome the problem with the rapid inactivation of GLP-1, have been developed (5, 119)