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The ASCT2/SLC1A5 and SNAT1/SLC38A1 genes were expressed at moderate levels, while the genes of ASCT1/SLC1A4 and SNAT5/SLC38A5 were at low levels in brain endothelial cells
In SURMOUNT-2 (Fras et al., NEJM 2023), participants with type 2 diabetes and obesity achieved mean weight reductions of 12.8% to 15.7% depending on dose
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