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Genetics, gut microbiome composition, baseline metabolic health, and how strictly someone follows diet and training all influence results

The researchers found that while semaglutide did not alter insulin sensitivity, as measured by pAkt:Akt ratio, it did significantly increase the expression of genes associated with mitochondrial biogenesis and function, including PGC-1, and TFAM

This is especially relevant given the known relationship between obesity, metabolic syndrome, and heart health risk

This study aimed to evaluate the effectiveness and safety of adding tirzepatide to insulin glargine in patients with type 2 diabetes who had inadequate control of blood sugar levels