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a 1993 wound-chamber rat study showed a 9-fold increase in collagen accumulation in GHK-Cu-treated wounds versus controls
Requires vitamin C cofactor (ascorbic acid) for proper crosslinking
This suggests that Ex-4 mediates its protective effects through a GLP-1-R-SIRT1-p53 signaling axis [41]
The delayed vasodilation, mediated by the SST neuron-astrocyte pathway, enhances the specificity of cerebral blood volume (CBV)-weighted fMRI signals to cortical layer 4, as confirmed by chemogenetic inhibition of SST neurons
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